Oral Presentation Skin Cancer 2024

Photoprotection Habits and Skin Cancer Risk Factors: Insights from the EUSCAP Project (#51)

Katharina KW Wunderlich 1 2 , Mariano MS Suppa 1 2 , Hassane HN Njimi 1 , Judith JL Lipski 1 2 , Wiam WAB Al Bouzidi 1 2 , Victoria VDW Deworme 1 2 , Appolline AE Wambreuse 1 2 , Sara SG Gandini 3 , Veronique VDM Del Marmol 1 2
  1. HUB - University Hospital Brussels, Brussels, Belgium
  2. Free University of Brussels, Brussels, Belgium
  3. Medical statistics, European Institute of Oncology, Milan, Italy

Euromelanoma, established in 1999, has been pivotal in advancing prevention, early diagnosis, and treatment of skin cancer. Operating in 39 countries, Euromelanoma has set up a substantial dataset from over 420,000 subjects, significantly contributing to our knowledge of skin cancer 1-6. This abstract introduces the Euromelanoma project “EUSCAP” (EUropean Skin CAncer risk factor Platform), initiated to comprehensively determine skin cancer risk factors in Europe. The EUSCAP project employs an extensive questionnaire, implemented since 2021, covering demographic, constitutional, behavioural, genetic, and clinical risk factors. Specifically, it introduces a sun exposure calendar that spans the patient’s lifetime, detailing professional, recreational, and intentional sun exposure for each stage of life. The attending physician's section captures genetic and clinical risk factors, including family history, naevi count, and histopathological reports7 . The current dataset of over 700 patients revealed distinct risk factors for melanoma (MM), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), as well as mixed skin cancers. Independent risk factors for MM included family history, naevi count, and solar lentigo. For BCC, risk factors included age, recreational sun exposure, and intentional exposure. SCC demonstrated associations with age, gender, personal history, actinic keratosis, and immunosuppression. Age, solar lentigo, and actinic keratoses were identified as independent risk factors for mixed skin cancers. While the study provides valuable insights, limitations include recall bias, social desirability bias, and potential recruitment bias. Future analyses will explore risk factors among subgroups (e.g. organ transplant recipients or outdoor workers).

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