Despite having the highest melanoma mortality rate in the world, investment in skin cancer prevention initiatives in Aotearoa New Zealand (NZ) has been minimal compared with Australia. Investigating the economic aspects of skin cancer can be crucial for illustrating the potential value of prevention initiatives and has contributed to the success of Australia’s comprehensive SunSmart program.1 This presentation will outline two ongoing projects led by members of the NZ Cancer Society Research Collaboration. The projects aim to: i) estimate the cost burden of skin cancer (keratinocyte cancer and melanoma) by demographics (age, sex and ethnicity), healthcare setting (primary care, specialist skin cancer clinics, secondary care) and cost category (health system, societal); and ii) evaluate the cost-effectiveness of various skin cancer prevention initiatives, including multifaceted skin cancer prevention campaigns, sun-protective school uniforms and shade development in schools. The presentation will cover the Markov model designs, key data sources, main findings and sensitivity analyses. Particular attention will be given to methodological aspects relevant to skin cancer simulation modelling. This will include assumptions regarding the treatment of benign legions, measuring productivity losses, and potential differential intervention effects by ethnicity and other demographic variables. Implications for policymakers, health promoters and researchers will be discussed.